Amphetamine Detox Methods
How is Medication Helpful in Amphetamine Detox?
Detox centers often use two types of treatments for those going through withdrawal from amphetamines: medication and therapy. Although currently there are no FDA-approved medications specifically designed to treat amphetamine withdrawal, there are several options that can help decrease the severity of symptoms, especially during the ” amphetamine crash.”
Although amphetamine withdrawal is rarely life-threatening, the process can be extremely uncomfortable and emotionally distressing. This emotional distress can lead to or worsen symptoms of depression, potentially increasing the risk of self-harm or suicide.
Amphetamine withdrawal is divided into three phases: early, subacute and protracted, and can last for one to three months, depending on certain factors such as duration, amount and frequency of use, overall health and any co-occurring mental health conditions. The early phase is considered the most intense and generally occurs within the first 24-72 hours after the last dose.
Antidepressants

Talk with your doctor about the best method for your amphetamine detoxification.
Medications such as buproprion or sertaline has been shown to help treat symptoms of depression and support mood stabilization.
Anti-anxiety medications
Anti-anxiety medications, including alprazolam, lorazepam or diazepam, are especially helpful in reducing anxiety, irritability and agitation. Because many of these medications have the potential for addiction, they should be used for the short-term and with close monitoring.
Antipsychotics
In some cases, antipsychotic medications like risperidone or olanzapine is used to treat the severe agitation, paranoia and psychosis that can present during amphetamine withdrawal. These medications are used for short-term treatment and usually in acute or inpatient settings only.
These medications should all be administered by medical professionals, and patients should know their risks as well as their benefits before starting this form of therapy.
It is critical to remember that detox itself is not a cure for amphetamine addiction. Medication, along with comprehensive treatment that includes therapy and aftercare, is the best way to support long-term recovery.
How is Therapy Helpful in Amphetamine Detox?
Detox is the beginning of a long road to recovery, but it is not the cure for addiction. While medications can help reduce withdrawal symptoms and manage cravings, therapy addresses the underlying causes of substance use.
Individuals who work with a therapist or counselor during and after detox are better prepared to cope with cravings, manage triggers and navigate high-risk situations without returning to drug use. Lasting sobriety requires meaningful lifestyle changes, and therapy helps build the insight, coping skills and support system necessary to sustain recovery.
Amphetamine withdrawal frequently includes the symptoms of depression, but in some cases, these symptoms may reflect an underlying mental health disorder that existed prior to substance use.
A qualified therapist can help assess and address these possibilities, exploring the emotional and psychological factors that contributed to drug use in the first place. Beggining therapy during detox also encourages continued engagement in treatment, reinforcing the importance of ongoing care beyond withdrawal management.
As emphasized by the Substance Abuse and Mental Health Services Administration (SAMHSA), fostering a patient’s entry into continued treatment and a full continuum of care is essential, highlighting why therapy plays such a critical role even in the earliest stage of amphetamine recovery.