Greensboro sits in Guilford County, which has experienced one of the more severe opioid crises in North Carolina. The county’s overdose death rate has historically exceeded the state average, and fentanyl contamination across the local drug supply has driven sustained public health investment.
Detox and substance use treatment facilities in Greensboro are licensed by the NC Division of Health Service Regulation (DHSR) under the NC Department of Health and Human Services (NCDHHS), which sets standards for staffing, clinical protocols and facility safety across all levels of care. The local managed care organization for Guilford County residents is Trillium Health Resources, the LME-MCO responsible for coordinating behavioral health, substance use and intellectual disability services.
Since July 2024, people with severe substance use disorders who receive NC Medicaid are enrolled in Trillium’s Tailored Plan, which bundles physical health, pharmacy and behavioral health coverage into a single plan. Trillium also offers a crisis line (1-888-302-0738) that operates 24/7 and can help connect callers with detox referrals.
Guilford County has committed $12.1 million in opioid settlement funds between 2023 and 2025, funding programs including GCSTOP’s low-barrier Medication for Opioid Use Disorder (MOUD) clinic, post-overdose response teams and naloxone vending machines placed throughout the county. The Guilford County Behavioral Health Center at 931 Third Street in Greensboro is open 24/7 for adults and adolescents in crisis.
